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"Spedia-NMR gave us rapid and efficient access to the concentration profiles of feed components and metabolites to fine-tune our cell culture process." Bram Bout, CTO at Profibrix

  "Spinnovation collaborated with Merck Sharp & Dohme on the development of NMR assays for biologics."             

Merck Sharp & Dohme

  "The Spedia-NMR™ service brings new insights into our cell lines metabolism which enables us to further optimize its performance." Vivalis.              

Call Us: +31-24-240-3400

Email: info@spinnovation-biologics.com

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Bioanalysis Technology

Bioanalysis Technology

Bioanalytical Expertise

We have developed a range of NMR methods and techniques for spent cell media bioanalysis plus a broad spectrum of analysis methods including LC-MS, LC-NMR, LC-SPE-NMR, LC-SPE-NMR-MS, for performing simple to complex profiling and characterization of biologics and biosimilars (including peptides, proteins, antibodies, oligo-/polysaccharides) or mixtures.

Spedia-NMR™ - Fast, Cost Efficient Spent Media Analysis

Our Spedia-NMR™ technology delivers fast, cost-effective, quantitative multiplex analysis of cell culture media. It rapidly evaluates what components your cell line is consuming and how they are being metabolized, including the production and accumulation of metabolites and toxic components.

All of this can be done in 96-well format, allowing for large batch analyses.

A Superior Approach To Nova Bioprofile (Flex) and HPLC

A rapid, robust and cost efficient method that outperforms LC-based method on all counts.

Unlike HPLC methods, Spedia-NMR™ does not require systematic calibration; there is no matrix or pH effect and because its data quality is not dependent on the user or machine, it delivers highly reproducible data.

This gives our clients the confidence that their results are reliable, and enables us to easily expand our capacity during peaks of demand.

pdf Download our Spedia-NMR™ Case Study.

pdf Download our Stem Cell Culture Optimization Case Study.

Spedia-NMR™ Vital Statistics

Over 40 analytes evaluated at a time.
Ideal linearity (R>=0.99) over a large dynamic range (10µM - >0.5M)
Concentration resolution of about 1%
Limit of detection of about 10µM

CHO batch culture analysis by Spedia NMRCHO batch culture analysis by Spedia NMR

 
 

Spinnovation Biologics is part of Sinensis Life Sciences

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